The Esophageal Pressure-Guided Ventilation 2 (EPVent2) trial protocol: a multicentre, randomised clinical trial of mechanical ventilation guided by transpulmonary pressure.

This trial showed a trend towards reduced mortality that was maintained at 6 months. 9 To further explore the use of P TP values to guide ventilation in patients with ARDS, our group, with the support of the National Heart, Lung and Blood Institute (NHLBI), has designed the EPVent2 study, a randomised clinical trial that aims to examine the impact of mechanical ventilation directed at maintaining a positive P TP in patients with moderate-to-severe ARDS.

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