highly significantP = 1.66 × 10 -8
However, a meta-analysis using a modified random effects model showed more highly significant P values: P = 1.66 × 10 -8 at rs34391416 ( EFCAB4A ), P = 7.56 × 10 -9 at rs147862429 ( CHID1 ), and P = 1.11 × 10 -8 at rs143705409 ( AP2A2 ).