Circulating biomarkers in advanced colorectal cancer patients randomly assigned to three bevacizumab-based regimens.

As an additional result, the Cox analysis of PFS and OS showed that worse prognosis was significantly associated with extension greater than 10 cm in all the models but that including CEA (data not shown); such a result was mainly due to the highly significant association between CEA and disease extension ( Table 3 ). 3.3.

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In our study, worse prognosis was associated with high baseline VEGF levels, although this correlation did not reach statistical significance.

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The table reports the results of the multivariable Cox models of PFS and OS, again showing that none of the biomarkers was significantly associated with prognosis; only SDF-1 showed a trend towards significance for OS, but did not reach the pre-specified significance limit of 5%.

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