Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.

To determine if any annotations were enriched in both mouse and human, even though individual genes were not shared, separate lists of genes nominally significant in human (915 genes p ≤ 0.05) and human homologues of the 42 mouse genes with p ≤ 0.05 were entered into DAVID.

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This shows that the overlap between our probes is highly significant, and that these 2971 genes really do coexpress with Mgst3 in the mouse hippocampus.

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Thus, we are able to identify genes associated with hippocampus size that may be significant, independent of whether individual SNPs are significant.

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