Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice.

Remarkably, by the 14th day of 60% CR (‘day 35’ of the experiment), the D1R KO mice no longer showed FAA ( Figure 8D,G ) and the difference with control mice was highly significant (p = 0.0003, Mann–Whitney).

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Initially the activity waveforms of the DD-VR mice showed a trend toward increased activity at night ( Figure 10B ), and they did not show appreciable FAA at the 7-day-time point (p < 0.05) ( Figure 10C ).

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