Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.

Breast Cancer Res Treat · 2014 · PMC4196136 · PMID 25253174

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

borderline significantp = 0.07so close (0.05 < p ≤ 0.1)

Interestingly, baseline ki-67 levels exhibited a borderline significant positive correlation with HOMA index ( r = 0.13, p = 0.07) and a negative correlation with IGFBP-1 ( r = −0.13, p = 0.07) (all data not shown).

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showed a trendno p-value reported

Metformin had a heterogeneous effect depending on markers of insulin resistance, which manifested itself in a tendency to decrease ki-67 levels in women with insulin resistance (approximately a quarter), defined by high levels of HOMA, C-peptide, IGFBP-3, and by low levels of free IGF-I and IGFBP-1, whereas it showed a trend to an increase of ki-67 in the majority of the remaining women.

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