ERRγ is not required for skeletal development but is a RUNX2-dependent negative regulator of postnatal bone formation in male mice.

PLoS One · 2014 · PMC4196935 · PMID 25313644

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showed a trendp = 0.069so close (0.05 < p ≤ 0.1)

Trabecular bone volume (BV/TV) and thickness (Tb.Th) were increased (21% and 10.8%, respectively) at 14 weeks, while trabecular separation (Tb.S) showed a trend (p = 0.069) towards a decrease at 8 weeks, and a significant decrease (16.5%) at 14 weeks in ERRγ +/− versus ERRγ +/+ mice ( Figure 2C ).

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