Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma.

In agreement with the proposed role for MITF in the transcriptional regulation of TYR, we found the expected trend in hnRNA and mRNA, although it did not reach statistical significance due to the high TYR hnRNA levels in one sample (MaMel69) ( Figure 5 C - D ).

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