Genetic modifiers of neurofibromatosis type 1-associated café-au-lait macule count identified using multi-platform analysis.

PLoS Genet · 2014 · PMC4199479 · PMID 25329635

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highly significantno p-value reported

near-significantno p-value reported

Both SNPs rs7161 and rs4660761 ( DPH2 and ATP6V0B ) were highly significant in a mega-analysis in a combined cohort of 180 self-reported European-Americans; SNP rs1800934 ( MSH6 ) was near-significant in a meta-analysis assuming dominant effect of the minor allele.

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marginally significantno p-value reported

In the meta-analysis, SNP rs7161 ( DPH2 ) was significant assuming dominant effect of the minor allele using untransformed CALM and SNP rs4660761 ( DPH2 ) and SNP rs1800934 ( MSH6 ) were marginally significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.