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Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway.

Br J Cancer · 2014 · PMC4200093 · PMID 25117814

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However, the correlation between fascin expression and overall survival in those patients did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.