Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials.

Analysis of the little data available on endothelial function [ 11 , 12 , 34 ] seems to confirm a beneficial effect of continuous treatment with PDE5i, although the data were almost entirely derived from ED patients [ 54 , 55 ], the effects did not reach statistical significance in patients with left heart disease, and there was very high heterogeneity (I 2 = 99%, P <0.001).

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In the main analysis, EF also improves, but with highly significant heterogeneity (I 2 84%).

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