nominally significantP =0.037
For primary anxiety response, those defined as responders at follow-up showed a small increase in SERT methylation during the treatment period (from pre- to posttreatment, +1.1%) at CpG site 4, whereas nonresponders showed a larger decrease in methylation (nominally significant;−5.9%, t (91)=2.114, P =0.037, d =0.499; see Figure 1a ).