Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study.

37 , 38 Somewhat surprisingly, there was a trend for smaller left (but not right) rostral limbic ACC volume to be associated with decreased risk of depression onset during adolescence (or, alternatively, that larger left rostral limbic ACC volumes were associated with increased risk for depression onset), and the mediating pathway from the 5-HTTLPR genotype to the left rostral limbic ACC volume to depression onset was also significant at the trend level.

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