Barely Significant
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significant at the trend level

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In the literature

significant at the trend levelp = 0.0541.1× alpha
When performing the same PLS analyses based on MD in each of the five brain regions ( Figure 2 , second row), only component 1 was significantly related to PTA (MD COMP1 : r = 0.59, p = 0.015), the second component was only significant at the trend level (MD COMP2 : r = 0.45, p = 0.054), and the third component was not significant (MD COMP3 : r = 0.09, p = 0.381).
More specifically, in the case of TOL, significant correlations were found with the following indicators: Execution time ( r = 0.60; p = 0.009), Total time ( r = 0.66; p = 0.002), Time above 1 min ( r = 0.62; p = 0.006), Total errors ( r = 0.50; p = 0.035), and a correlation significant at the trend level with the Extra moves ( r = 0.42; p = 0.07).
significant at the trend levelp = 0.0771.5× alpha
Including both a positive THC screen and past or current SUD as additional covariates in the analyses strengthened the main group effect [F(1,41) = 9.02, p = 0.005; partial η 2 = 0.18, generally considered a medium effect size]; the group × region interaction continued to be significant at the trend level ( p = 0.077), Greenhouse–Geisser corrected.
Interestingly, a recent ESM study examining individuals with 22q11.2 deletion syndrome (a syndrome associated with learning difficulties, a range of physical health problems, and psychiatric comorbidity—including psychosis), reported that cortisol levels in the healthy control group, but not the 22q11.2 deletion syndrome group, increased in parallel with activity related stress, but that this association in controls was only significant at the trend level ( 80 ).