Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Transl Psychiatry · 2014 · PMC4203017 · PMID 25247594

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

0.0400

boldest claim

The sentences

marginal significanceP =0.04actually significant

7 ( N =127), and the marginal significance reported by Caselli et al. 6 ( P =0.04) caution that previous significant findings may to an extent reflect type 1 error.

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nominally significantno p-value reported

This study investigated the independent effects of these polymorphisms on human cognitive ageing, and the extent to which nominally significant associations with cognitive ageing were mediated by previously reported genetic associations with brain white matter tract integrity in this sample.

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