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Immunoglobulin E plays an immunoregulatory role in lupus.

J Exp Med · 2014 · PMC4203948 · PMID 25267791

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a strong trendno p-value reported
2 a , production of anti-dsDNA, anti-ribonucleoprotein (RNP), or anti-histone IgG was significantly decreased in FcγRIIB −/− .Yaa Igh7 −/− mice and in FcγRIIB −/− Igh7 −/− mice, and there was a strong trend toward decreased responses as well.

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