Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.

Mov Disord · 2014 · PMC4204174 · PMID 25112864

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did not reach statistical significanceno p-value reported

Mean S129D α-Syn-HA protein levels were also down-regulated in the other five regions analyzed, this was significant for the cerebellum (decreased 45%), brain stem (decreased 29%), thalamus (decreased 44%), and spinal cord (decreased 30%), although these did not reach statistical significance for the olfactory lobe (decreased 16%) (Supplemental Data Fig. 4A, B).

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