Evolutionary rate depends on number of protein-protein interactions independently of gene expression level.

In protein interaction data sets generated by the computational methods of gene co-occurrence and gene neighborhood, a weakly significant correlation between number of interactions and evolutionary rate remained when expression levels were statistically controlled [ 7 ].

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To emphasize that the measurable effect of number of interactions on evolutionary rate remains highly significant even when controlling for expression, we presented a re-analysis of mass spectrometry interaction data.

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