Circulating MicroRNAs as easy-to-measure aging biomarkers in older breast cancer patients: correlation with chronological age but not with fitness/frailty status.

Nonetheless, it is quite remarkable that such highly significant age-related changes in circulating miRNAs, as observed in our study for miR-301a, miR-20a-3p, miR-106b-5p, miR-191 and miR-30b-5p, can be evidenced with as little as 10 patients per age group, suggesting that these miRNAs can be considered as robust and reliable aging biomarkers.

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The remaining miRNAs included in the validation study (miR-21, miR-210, miR-320b, miR-378, miR-423-5p, let-7d, miR-140-5p, miR-200c, miR-374a, miR376a) all showed similar trends as observed in the exploratory screening but these differences did not reach statistical significance.

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