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Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates.

PLoS Pathog · 2014 · PMC4207810 · PMID 25340543

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Mock vaccinated NHPs also exhibited a trend in increased serum alanine transaminase (ALT), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) levels, indicating liver, kidney, and other tissue damage, although these levels did not reach statistical significance over those of the vaccinated NHPs, perhaps due to small sample size ( Fig.

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