Acid suppression therapy does not predispose to Clostridium difficile infection: the case of the potential bias.

Each medication was associated with an increased likelihood of CDI when CDI cases were compared to untested controls, however with p-values approaching significance (OR H2RA = 1.99, p-value = 0.075 and OR PPI = 1.82, p-value = 0.077).

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In other words, CDI cases were not different from the controls suspected for having CDI (and thus tested) in terms of their exposure to H 2 RA (p-value = 0.511), but their exposure to H 2 RA was higher compared to the controls without a test (at borderline significance level of 0.074).

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