Typhimurium replication The difference in survival between Nramp-Cg and Nramp-Tg mice did not reach statistical significance on day 50 ( Figure 4 ), suggesting that Nramp1 overexpression in Nramp-Tg mice does not enhance the overall control of bacterial replication compared with Nramp-Cg hosts.
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Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.
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