Causality assessment for suspected DILI during clinical phases of drug development.

Drug Saf · 2014 · PMC4212150 · PMID 25352327

Europe PMC DOI

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a clear trendno p-value reported

However, if the subsequent ALT level shows a clear trend upwards, it is advisable to initiate a full evaluation to allow for a comprehensive causality assessment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.