Toward rapid, high-sensitivity, volume-constrained biomarker quantification and validation using backscattering interferometry.

Lung nodules of indeterminate significance are discovered in over 25% of the individuals screened with CT. 32 As revealed by expensive and invasive diagnostic tests used to discriminate these lesions, 96% of these hard to distinguish nodules are benign. 33 The development of a simple, rapid, specific, noninvasive, and clinically relevant diagnostic tool would improve early lung cancer detection, reduce the need for unnecessary biopsies, and enable early treatment.

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