Induction of enhanced acoustic startle response by noise exposure: dependence on exposure conditions and testing parameters and possible relevance to hyperacusis.

However, in the animals exposed at 115 dB SPL, the increases in ASR amplitude were highly significant at all stimulus levels from 105–120 dB SPL ( Fig. 4D ) (F 3,80 = 38.57, P<0.0001) and followed an initial period when startle responses were decreased below control levels ( Fig. 4C ).

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When the data were averaged across animals on days 7–9 post-exposure, those exposed at 110 showed a trend suggestive of startle enhancements at high startle stimulus levels (≥105 dB SPL) (F 3,72 = 6.21, P = 0.01), but the enhancement was significant only at a startle stimulus level of 110 dB SPL (T 9 = 1.83, P = 0.05) ( Fig. 4B ).

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