Barely Significant
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Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study.

Respir Res · 2014 · PMC4220061 · PMID 25331383

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However, the relationship between night-time symptoms and COPD severity did not reach statistical significance and the proportion of patients with night-time symptoms was similar across all severities (58.9–65.9%; Figure 4 B).

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