Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

For the minor allele of rs2900478 ( SLCO1B1 ), the borderline significant association with smaller magnitude of LDL-C reduction showed a trend for preferential association with larger versus smaller LDL subfractions.

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The minor allele of SORT1 rs646776 was associated with greater statin-induced reductions in levels of all LDL subfractions, and there was a nonsignificant trend for larger effect sizes and greater statistical significance for lowering of small and very small LDL ( Table 2 ).

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