In subgroup analyses by study design for the highest category vs lowest, the pooled association estimates of LC n-3 PUFA including the specific subtypes were all significant in prospective cohort studies, although the pooled estimate of C20:5n-3 and C22:5n-3 from case-control studies did not reach statistical significance.
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Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals.
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