The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study.

As shown in Table 2 , the presence of synchronous metastases did not have a significant effect on the survival of patients with the smaller tumors <5.5 cm (P = 0.63), but it had a highly significant effect on the survival of patients with larger tumors ≥5.5 cm (P = 0.0003).

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Patients with PHEO had possibly worse, though it did not reach statistical significance, overall survival than those with PGL (P = 0.099); their survival was not affected by the size of the primary tumor or by synchronous metastases.

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