Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat lung preparation: Role of mitogen-activated protein kinase/Akt signaling and the effects of theophylline.

22 Deflation and reinflation decreased the lung cAMP content (57 ± 6.9 and 42.2 ± 2.3 pmol/mL, respectively, compared with baseline, 67.6 ± 6.0 pmol/mL), but the difference failed to reach statistical significance ( Figure 5 , A ).

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