MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis.

Genome Biol · 2014 · PMC4226881 · PMID 25348067

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nominally significantno p-value reported

However, many have nominally significant P -values by MSEA-clust, even though they failed multiple testing corrections, for example, TP53 in LAML (nominal p clust =0.02, p domain =5.12 × 10 -3 ), SMAD4 (SMAD family member 4) in COADREAD (nominal p clust =0.016, p domain =1.43 × 10 -5 ), and CDK12 (cyclin-dependent kinase 12) in OvCa (nominal p clust =8.31 × 10 -3 , p domain =9.08 × 10 -4 ), among others.

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