Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer.

The lower fraction of tumours with collagen pathway mutations at higher lymph node stages (N3, N4), and with ECM-related mutations in tumour stages III and IV could be related to clonal selection of distinct metastatic phenotypes 35 , however it is also possible that the decreases may not be significant due to the lower numbers of tumours in these categories.

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Thirteen genes identified as significantly mutated in breast cancer by the TCGA did not reach statistical significance within our study ( Table S4 ).

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