Cross-space-time clustering of childhood cancer in Great Britain: evidence for a common aetiology.

Formal statistical significance was taken as p < 0.00067 and marginal significance 0.01 > p ≥ 0.00067.

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Based on address and date of birth, there was marginally significant cross-clustering between cases of lymphoid leukemia (LL) aged 5-14 years and Hodgkin lymphoma (HL) aged 0–14 years ( p = 0.0019).

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The choice of the formal significance level of p < 0.00067 has guarded against the possible effect of multiple testing leading to spurious nominally significant results.

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