Loss of PPARγ expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment.

Similarly, DMBA + ROSI-treated PPARγ-MSE KO mice showed a strong trend toward decreased median overall survival (Fig. 2 b ), reaching a 50% plateau at week 18.5, as compared to similarly treated control mice that did not reach median overall survival by 25 weeks ( p = 0.06).

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