Lobular breast cancers lack the inverse relationship between ER/PR status and cell growth rate characteristic of ductal cancers in two independent patient cohorts: implications for tumor biology and adjuvant therapy.

In contrast to the above-mentioned similar Ki67 correlations in ILC and IDC, there was a highly significant inverse relationship between ER/PR status and high-Ki67 subset for IDC in both cohorts ( p ≤0.002; Table 4 ), but no significant relationship between ER or PR status and high/low Ki67 subset for ILC irrespective of whether evaluated separately or together ( p >0.6; Table 3 ).

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This relationship did not reach statistical significance for the individual AUS-ILC ( p <0.06) or HK-ILC cohorts ( p <0.09) with respect to tumor size, perhaps reflecting lower numbers relative to IDC counterparts, nor for the AUS-ILC cohort with respect to HER2 status ( p =0.28); however, the latter value reduced to p =0.06 following age correction, suggesting confounding due to very low numbers (one case only) of HER2-positive ILC in the older AUS cohort.

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