Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs.

The trend is weaker in lincRNAs compared with protein-coding genes (rho = 0.2 and 0.28, respectively) but both correlations are highly significant (from Spearman: P < 10 − 16 ).

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Alternatively, there may not be a monotonic relationship between expression level and rate, in which case sampling only the more highly expressed transcripts could enable detection of a strong trend unique to the highly expressed genes.

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