Oxidative stress in susceptibility to breast cancer: study in Spanish population.

Other studies found a borderline significance [ 18 ].

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The polymorphism on the SOD3 gene (rs2284659) analyzed in our study showed a trend to the predisposition for BC in the global analysis.

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Thereupon, we chose the polymorphisms that showed marginally significant association (p-value < = 0.15), and we replicated the procedure in a second independent group (n = 1233) where we included 430 female patients diagnosed for BC between the years 1988–1998 at the Clinic Hospital of Valencia (Spain) and 803 samples from cancer-free women recruited at the blood donor bank at the same Hospital.

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We, however, were unable to confirm this in our global analysis, although we detected a marginal significance in set 1.

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