Given the association of CGI shores with tissue-specific methylation [ 19 ], we extended our search to CGIs including +/- 1 kbp of flanking sequence, which yielded sets of nominally significant motifs [see Additional file 2 : Figure S1.A].
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Protection of CpG islands against de novo DNA methylation during oogenesis is associated with the recognition site of E2f1 and E2f2.
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