A striking difference was apparent between HCP and LCP, both for the GC content fraction and the occurrence of CpG sites in relation to the transcription start site (TSS) ( fig. 3 and supplementary fig.
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Conserved and divergent patterns of DNA methylation in higher vertebrates.
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The sentences
The highly significant deviation of CpG sites in the promoters from the Poisson expectation strongly supports their nonrandom distribution.