If analyses were ended in 1987, a strong trend of progressively increasing hazard of hypercholesterolemia with increasing PFOA exposure was seen in analyses combining ages and sexes, for both the cumulative (log-linear trend test p < 0.001) and yearly metrics (log-linear trend test p < 0.001) (see Supplemental Material, Figure S7 for yearly metric results).
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Modeled PFOA exposure and coronary artery disease, hypertension, and high cholesterol in community and worker cohorts.
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The sentences
In retrospective analyses varying the year in which the analysis was ended, an apparent trend (although not completely monotonic) of increasing hypertension hazard with increasing cumulative PFOA exposure quintile was seen for sexes and ages combined in analyses ending in 1987; this trend became progressively less clear with longer follow-up after the time of peak exposure (see Supplemental Material, Figure S5).