Monoamine metabolites were not assessed in the present biomarker screening study but pilot work demonstrated that 14 weeks of dosing at 2 mg kg −1 per day significantly increased CSF serotonin and showed a trend for decrease of the serotonin metabolite 5HIAA. 47 Discussion Drugs that increase monoamine levels in the synaptic cleft are used for the treatment of a variety of psychiatric diseases.
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Identifying individual differences of fluoxetine response in juvenile rhesus monkeys by metabolite profiling.
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