Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L.

Thereby, we observed that anti-Tim3 mAb was able to significantly reduce the secretion of TNF, VEGF-A and IL-8 (median reduction: 36, 70 and 23%, respectively) but not of IL-1 β and IL-6, although most of the CCs from different donors showed a trend toward a reduced production of these cytokines.

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