Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.

The data showed a trend for increased survival rates for mice infected with the ΔsaTlp1/ΔsaTlp2 mutant, most noticeably in the case of infection with 10 5 CFU when 2 of 6 mice challenged with mutant bacteria survived until day 6 of the experiment whereas all mice infected with wild-type had died by day 2 ( Figure 8 ).

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