Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala.

Three of these traits (“Attention/Cognition,” “Depression/Immobility,” “Metabolism/Body weight gain”) were overrepresented showing a significant correlation ( P < 0.05) with impulsivity, whereas one trait (“Anxiety/Novel open field”) showed a trend ( P < 0.10) toward overrepresentation.

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Similarly to the axonal guidance, both of these pathways seem to be more affected by the positively correlated miRNAs (miR-28a-5p, miR-340-5p, and miR-491-5p) rather then the negatively correlated one (miR-219a-5p), of which the effect on these pathways is barely significant (Table 7 ).

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