Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice.

However, the differences in hepatic Shp expression in vivo between chow-fed FXRα2- and FXRα4-expressing mice failed to reach statistical significance and therefore the physiological relevance, if any, of isoform-specific Shp regulation awaits further studies.

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