CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.

Even though there was a trend toward reduced median velocity that did not reach statistical significance ( Fig. 4 C ), their motility coefficient was reduced by 35% ( Fig. 4 D ), and cells within perisinusoidal niches were significantly less amoeboid ( Fig. 4 E ).

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The number of pro-B and pre-B cells was slightly but significantly reduced in BM, which corresponded to a small, but highly significant numerical increase in blood circulation ( Fig. 3, A and B ).

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