Induction of hypertension along with STZ-induced diabetes produced a 500-fold increase in albuminuria, glomerulosclerosis and tubular interstitial fibrosis, while GFR tended to be lower in both diabetic and non-diabetic TTRhRen rats, but did not reach statistical significance.
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The sentences
Taken together our results suggest that HD mice represent a robust model of type I DN that recapitulates key features of human disease which may be significant in studying the pathogenesis of DN and in the assessment of putative therapeutics.