In the NSFT, in a novel cage testing environment, we observed a strong trend to decreased latency to feed in control animals in response to ketamine injection (24 hr post-injection) as expected (Cont = 207.4 ± 70.6 s vs Cont + Ket = 58.7 ± 29.4 s, p = 0.17).
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GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine.
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