Effects of Treg cells and IDO on human epithelial ovarian cancer cells under hypoxic conditions.

Results Expression of the IDO mRNA under different conditions The IDO mRNA expression level showed a decreasing trend (P<0.05) with prolonged exposure to hypoxia in SKOV3-IP ( Fig. 1A ), and in SKOV3-IP + CTL cells (P<0.05) ( Fig. 1B ).

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Discussion The expression of IDO in ovarian cancer cells showed a significant trend to decrease at the mRNA and protein level along the time of exposure to hypoxic conditions ( Figs. 1 and 2 ), and these findings are consistent with a previous study ( 16 ).

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