Differential NF-κB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.

The NaF- and TPA-induced CXCL8 releases were partially suppressed (~50% and ~40% reduction, respectively) by siRNA, although inhibition of the TPA-induced response did not reach statistical significance ( Figure 9A ).

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